Kapil Gadkar: search on Z-Library

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1

gPKPDSim: a SimBiology®-based GUI application for PKPD modeling in drug development

Hosseini, Iraj, Gajjala, Anita, Bumbaca Yadav, Daniela, Sukumaran, Siddharth, Ramanujan, Saroja, Paxson, Ricardo, Gadkar, Kapil

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2018

Language:

english

File:

PDF, 2.23 MB

english, 2018

2

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain

Gadkar, Kapil, Yadav, Daniela Bumbaca, Zuchero, Joy Yu, Couch, Jessica A., Kanodia, Jitendra, Kenrick, Margaret K., Atwal, Jasvinder K., Dennis, Mark S., Prabhu, Saileta, Watts, Ryan J., Joseph, Sean

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2016

Language:

english

File:

PDF, 2.15 MB

english, 2016

3

Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model

Hutton-Smith, Laurence A., Gaffney, Eamonn A., Byrne, Helen M., Maini, Philip K., Gadkar, Kapil, Mazer, Norman A.

Journal:

Molecular Pharmaceutics

Year:

2017

Language:

english

File:

PDF, 789 KB

english, 2017

4

Estimating optimal profiles of genetic alterations using constraint-based models

Kapil G. Gadkar, Francis J. Doyle III, Jeremy S. Edwards, Radhakrishnan Mahadevan

Journal:

Biotechnology and Bioengineering

Year:

2005

Language:

english

File:

PDF, 303 KB

english, 2005

5

Modest reductions in BACE1 activity significantly reduce beta-amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease

Meilandt, William, Atwal, Jasvinder, Gadkar, Kapil, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Watts, Ryan, Scearce-Levie, Kimberly

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 43 KB

english, 2013

6

A Six-Stage Workflow for Robust Application of Systems Pharmacology

Gadkar, Kapil, Kirouac, Daniel, Mager, Don, van der Graaf, Piet H., Ramanujan, Saroja

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.88 MB

english, 2016

7

SC3.4 - Therapeutic area case study: QSP in inflammatory disease

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2020

File:

PDF, 59 KB

2020

8

Optimal genetic manipulations in batch bioreactor control

Kapil G. Gadkar, Radhakrishnan Mahadevan, Francis J. Doyle III

Journal:

Year:

2006

Language:

english

File:

PDF, 363 KB

english, 2006

9

On-line adaptation of neural networks for bioprocess control

Kapil G. Gadkar, Sarika Mehra, James Gomes

Journal:

Computers & Chemical Engineering

Year:

2005

Language:

english

File:

PDF, 362 KB

english, 2005

10

Cybernetic Model Predictive Control of a Continuous Bioreactor with Cell Recycle

Kapil G. Gadkar, Francis J. Doyle III, Timothy J. Crowley, Jeffrey D. Varner

Journal:

Biotechnology Progress

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

11

Mechanisms Mediating Anti-CD3 Antibody Efficacy : Insights from a Mathematical Model of Type 1 Diabetes

DANIEL L. YOUNG, SAROJA RAMANUJAN, HUUB T.C. KREUWEL, CHAN CHUNG WHITING, KAPIL G. GADKAR, LISL K.M. SHODA

Journal:

Annals of the New York Academy of Sciences

Year:

2006

Language:

english

File:

PDF, 166 KB

english, 2006

12

The Virtual NOD Mouse : Applying Predictive Biosimulation to Research in Type 1 Diabetes

YANAN ZHENG, HUUB T. C. KREUWEL, DANIEL L. YOUNG, LISL K. M. SHODA, SAROJA RAMANUJAN, KAPIL G. GADKAR, MARK A. ATKINSON, CHAN C. WHITING

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 245 KB

english, 2007

13

Dosing and Timing Effects of Anti-CD40L Therapy : Predictions from a Mathematical Model of Type 1 Diabetes

KAPIL G. GADKAR, LISL K. M. SHODA, HUUB T. C. KREUWEL, SAROJA RAMANUJAN, YANAN ZHENG, CHAN C. WHITING, DANIEL L. YOUNG

Journal:

Annals of the New York Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 84 KB

english, 2007

14

In Vivo and In Silico Modeling the Dynamics of Autoimmune Diabetes

Qizhi Tang, Yanan Zheng, Jason Adams, Huub Kreuwel, Kapil Gadkar, Cristina Penaranda, Lisl Shoda, Chan C. Whiting, Daniel Young, Jeffrey Bluestone

Journal:

Clinical Immunology

Year:

2007

Language:

english

File:

PDF, 40 KB

english, 2007

15

Iterative approach to model identification of biological networks

Kapil G Gadkar, Rudiyanto Gunawan, Francis J Doyle

Journal:

BMC Bioinformatics

Year:

2005

Language:

english

File:

PDF, 530 KB

english, 2005

16

[IEEE 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Lyon, France (2007.08.22-2007.08.26)] 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Towards Optimal Virtual Patients: An Online Adaptive Control Approach

Ghosh, Samik, Young, Daniel L., Gadkar, Kapil G., Wennerberg, Leif, Basu, Kalyan

Year:

2007

Language:

english

File:

PDF, 1.01 MB

english, 2007

17

Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates

Sukumaran, Siddharth, Gadkar, Kapil, Zhang, Crystal, Bhakta, Sunil, Liu, Luna, Xu, Keyang, Raab, Helga, Yu, Shang-Fan, Mai, Elaine, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ramanujan, Saroja, Jun

Journal:

Pharmaceutical Research

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

18

Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach

Gadkar, Kapil, Lu, James, Sahasranaman, Srikumar, Davis, John, Mazer, Norman A., Ramanujan, Saroja

Journal:

The Journal of Lipid Research

Year:

2016

Language:

english

File:

PDF, 1.55 MB

english, 2016

19

Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics

Sukumaran, Siddharth, Zhang, Crystal, Leipold, Douglas D., Saad, Ola M., Xu, Keyang, Gadkar, Kapil, Samineni, Divya, Wang, Bei, Milojic-Blair, Marija, Carrasco-Triguero, Montserrat, Rubinfeld, Bonnee,

Journal:

The AAPS Journal

Year:

2017

Language:

english

File:

PDF, 1.51 MB

english, 2017

20

Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

Kirouac, Daniel C., Schaefer, Gabriele, Chan, Jocelyn, Merchant, Mark, Orr, Christine, Huang, Shih-Min A., Moffat, John, Liu, Lichuan, Gadkar, Kapil, Ramanujan, Saroja

Journal:

npj Systems Biology and Applications

Year:

2017

Language:

english

File:

PDF, 3.53 MB

english, 2017

21

Modeling and Analysis Challenges in Systems Biology

Gadkar, Kapil G., Gunawan, Rudiyanto, Doyle, Francis J.

Journal:

IFAC Proceedings Volumes

Year:

2004

Language:

english

File:

PDF, 15.56 MB

english, 2004

22

Widespread brain distribution and activity following anti-BACE1 intracerebroventricular infusion in nonhuman primates

Bumbaca Yadav, Daniela, Maloney, Janice A, Wildsmith, Kristin R, Fuji, Reina N, Meilandt, William J, Solanoy, Hilda, Lu, Yanmei, Peng, Kun, Wilson, Blair, Chan, Pamela, Gadkar, Kapil, Kosky, Andrew, G

Journal:

British Journal of Pharmacology

Year:

2017

Language:

english

File:

PDF, 812 KB

english, 2017

23

Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3

Slaga, Dionysos, Ellerman, Diego, Lombana, T. Noelle, Vij, Rajesh, Li, Ji, Hristopoulos, Maria, Clark, Robyn, Johnston, Jennifer, Shelton, Amy, Mai, Elaine, Gadkar, Kapil, Lo, Amy A., Koerber, James T

Journal:

Science Translational Medicine

Year:

2018

Language:

english

File:

PDF, 4.65 MB

english, 2018

24

Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics

Gadkar, Kapil, Pastuskovas, Cinthia V., Le Couter, Jennifer E., Elliott, J. Michael, Zhang, Jianhuan, Lee, Chingwei V., Sanowar, Sarah, Fuh, Germaine, Kim, Hok Seon, Lombana, T. Noelle, Spiess, Christ

Journal:

Investigative Opthalmology & Visual Science

Year:

2015

Language:

english

File:

PDF, 2.47 MB

english, 2015

25

gQSPSim: a GUI application based on SimBiology Â® for standardized QSP model development and application

Hosseini, Iraj, Feigelman, Justin, Gajjala, Anita, Susilo, Monica, Ramakrishnan, Vidya, Ramanujan, Saroja, Gadkar, Kapil

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2020

Language:

english

File:

PDF, 19.03 MB

english, 2020

26

Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling

Hosseini, Iraj, Gadkar, Kapil, Stefanich, Eric, Li, Chi-Chung, Sun, Liping L., Chu, Yu-Waye, Ramanujan, Saroja

Journal:

npj Systems Biology and Applications

Year:

2020

File:

PDF, 1.86 MB

2020